ROLE OF LIQUID BIOPSY IN DIAGNOSIS OF ORAL CANCER

Abstract

Liquid Biopsies is a new field of study with increased potential for improving early cancer detection, therapeutic modification, surveillance of disease recurrence. Oral cancer is the most common form of cancer.Inadequate screening leads This review provides knowledge of the current biological and clinical significance of circulating tumour cells (CTCs), circulating tumour DNA (ctDNA), and exosomes for diagnosis and prognosis of oral cancer. It also highlights the importance of liquid biopsy using blood and saliva which suggests a potential alternative to solid biopsy for diagnosis and prognosis. Early detection and surveillance of oral cancer is the goal for achieving patients outcomes. Clinical examination and biopsy of the suspected oral lesion followed by histological analysis are usually used for diagnosis. Biopsy is the gold standard ,an invasive procedure in which a portion of the suspected malignant tissue is obtained and further subjected to specialized and sophisticated histopathology or cytology procedures.