AN IN SILICO ANTISENSE RNA MOLECULES PREDICTION FOR SARS-COV-2 SPIKE PROTEIN INHIBITION

Authors

  • Mona N. Al-Terehi, Raad N. Hasan, Methak J. AL-Jboory

Abstract

The present study was suggested as an in silico design of antisense RNA molecules as a preliminary suggestion for virus suppression, the spike protein DNA sequences of SARS-CoV-2  virus  which isolates in  Wuhan-Hu-1(MN908947.3)  was used for prediction secondary structure, then RNA antisense molecules designs according to GC%, probabilities and energy, the predictions refer that the secondary structure of RNA is complex and have more than one regions for antisense creation, eight    regions for antisense RNA , the first region (59-82)n, second (880-899), third (1141-1160), forth (1647-1668), fifth (1875-1895), sixth (2022-2052), seventh (2417-2445) and finally eighth (2804-2828). Each region has 1-4 target sites , The characteristics of antisense RNA also listed in the table, the GC% percentages were (45-50) %, the probabilities ranged (0.686-0.974) and energy (-0.1 – 12.8) kcal/mol

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Published

2020-11-15

How to Cite

Mona N. Al-Terehi, Raad N. Hasan, Methak J. AL-Jboory. (2020). AN IN SILICO ANTISENSE RNA MOLECULES PREDICTION FOR SARS-COV-2 SPIKE PROTEIN INHIBITION. PalArch’s Journal of Archaeology of Egypt / Egyptology, 17(7), 7607-7615. Retrieved from https://archives.palarch.nl/index.php/jae/article/view/3374