INTERPLAY OF OXIDATIVE STRESS AND LIPOPROTEINS IN BREAST CARCINOMA INITIATION, PROMOTION AND PROGRESSION – A SYSTEMATIC REVIEW

Abstract

Breast tumor is an epigenetic cancer and its diagnosis suggests that it is lifestyle mediated.  One of the target structures affected by reactive oxygen species is lipids and their interaction in lipid peroxidation. The aim of the present systematic review is to assess the interplay of oxidative stress and lipoprotein in breast tumor initiation, promotion and progression. We conducted a qualitative systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The search covers articles ranging from the year 2010 to 2020. The Database includes PubMed, Cochrane, ScienceDirect and Google scholar. The Medical Subject Headings used for search include ‘Breast tumor’ ‘Lipoprotein’ ‘Oxidative stress’ ‘gene expression’. The records are assessed for its quality using Cochrane Risk of bias assessment tool. After the screening process 05 full text articles are selected for the study and are at low risk of bias. The findings suggest that oxidized form of high density and low density lipoprotein forms a crucial role in the cellular behavior of breast tumor cells in its initiation, proliferations, progression and invasiveness. The lipolysis enzyme and its protective role in cancer cell survival against oxygen species through lipid droplet accumulation and promoting the cell survival, preventing cell death from metabolic starvation is becoming evident.